Protein Details: Transient receptor potential channel pyrexia

Protein ID

ICDB_Pro_1683

Protein Name

Transient receptor potential channel pyrexia

Gene Name

pyx; CG17142

Organism

Drosophila melanogaster (Fruit fly)

Length

956 amino acids

AlphaFoldDB

AF-Q9W0T5-F1-model_v4.pdb

Function

Sequence

MENVRFSIIENDLKWNSESDPTADVDLLLDKRSISSEANSAGVFSDEAHEIFARQQQNQILWDLDEVKETLTESPGGKHVVDMVQSGCFLELMTDSADCNLALICCSVFGSVENTLFLLKHYNADPNVADSRGRTPLHFACCRANAPIAKVLLDFGADPNRWDARKEVTSLHCAASSKSVECILLLLRRKASINIGIEKRSALHYAIDVNAVDCVEILLKYGADPNTPQVYTETPLHTASAAGFAKCVQLLLSHNADVRSQFGEGKVTALHLAAENDYVECARLLLEHRAEVDCRNASHQTPLHLACLSQSIGTVDLLISYGANVNAVYRDGRTALHAAIVKQSRSLDCCNALLKAGADVNKADNYGYTPLHIAALNEFSSCVYTFIEHGADITARTDGRVSALSFIVRRTPEIIPKLMQKLDSSIKANDQEIGDVDCQIKLDFRLLVPSSSMDRGETELLLSLIEVGQKRILMHPLCETFLFLKWRRIRKFFLMSLAYHTLFVILFTFYVIWVYVRCCKKEELCVAPGYVSTIGYLVIILNLILLGKEVFQMAHGLRGYAKYWENWLQWTIGTGVLLCVTPETVRTDDLTAVPVWQHHVAAIVILLVWLELMMLVGRFPIFGVYVQMFTKVAVNFAKFLLAYICLLVAFGLSFAVLFNDYPAFENITWSFLKSITMMSGELEFEDIFYGDYAVKFPVTAHIIFLSFVLLVTVILTNLMVGLAVSDIQGLQVSATLDRLVRQAELVSRLESLFFSRLLRSAPTNLIQLCKRSALLRTSRDKLQFTIRPNDPRDNQLPEDIKLNVYKLVAERRDRNQSLRRRQFENNYNIFSRSLQRQQQPLHTDFLKPEPATGTTKKTPQNLFHMHELLRPRSATNVPQQFRQEAEGTVQMKNQANVLSAVLAEVQAIKTQLVDLVAKFERFSENATRKLNYSTDELCRLRQQGQSVASSHIRRHR

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Expressed in various peripheral nerves and the central nerves in embryos. In adults; it is expressed in sensory neurons lying beneath the bristles around eyes; neurons innervating the bristles on the back of thorax and neurons in maxillary palps; proboscis and antennae. Expressed in multidendritic neurons; which mediate temperature sensing; as well as non-multidendritic neurons in larval epidermis. Expressed in multidendritic neurons; which mediate temperature sensing; as well as non-multidendritic neurons in larval epidermis. Expressed in multidendritic neurons; which mediate temperature sensing; as well as non-multidendritic neurons in larval epidermis. Localizes ubiquitously throughout neurites. .

DOI ID

10.1126/science.287.5461.2185; 10.1186/gb-2002-3-12-research0083; 10.1186/gb-2002-3-12-research0080; 10.1038/ng1513

RefSeq

NP_612015.1 [Q9W0T5-1]; NP_728501.1 [Q9W0T5-2]